Pharmacokinetics and safety of fluconazole in young infants supported with extracorporeal membrane oxygenation.

ABSTRACT:

Background

Candida infections are a leading cause of infectious disease-related death in infants supported with extracorporeal membrane oxygenation (ECMO). The ECMO circuit can alter drug pharmacokinetics; thus, standard fluconazole dosing in children on ECMO may result in suboptimal drug exposure. This study determined the pharmacokinetics of fluconazole in infants on ECMO.

Methods

Infants <120 days of age received either intravenous fluconazole prophylaxis (25 mg/kg once a week) or treatment (12 mg/kg daily) while on ECMO. Paired plasma samples were collected preoxygenator and postoxygenator around doses 1 and 2 to calculate pharmacokinetic indices and describe oxygenator extraction. A 1-compartment model was fit to the data using nonlinear regression. Surrogate pharmacody

SUBMITTER: Watt KM 

PROVIDER: S-EPMC3444624 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature