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Genetic analysis of an ambler class A extended-spectrum beta-lactamase from Capnocytophaga ochracea.

ABSTRACT: A beta-lactamase gene (cfxA3, 966 bp) was isolated from a beta-lactam-resistant Capnocytophaga ochracea clinical isolate and amplified using primers from the cfxA gene of Bacteroides vulgatus. The MICs of third-generation cephalosporins were much higher than those of the transconjugant Escherichia coli strain. The deduced protein sequence, by comparison with CfxA2 of Prevotella intermedia, had a Y239D substitution and possessed the characteristics of a class A, group 2e beta-lactamase.

SUBMITTER: Jolivet-Gougeon A 

PROVIDER: S-EPMC344468 | biostudies-literature | 2004 Feb

REPOSITORIES: biostudies-literature

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Genetic analysis of an ambler class A extended-spectrum beta-lactamase from Capnocytophaga ochracea.

Jolivet-Gougeon Anne A   Tamanai-Shacoori Zohreh Z   Desbordes Laurent L   Burggraeve Nathalie N   Cormier Michel M   Bonnaure-Mallet Martine M  

Journal of clinical microbiology 20040201 2

A beta-lactamase gene (cfxA3, 966 bp) was isolated from a beta-lactam-resistant Capnocytophaga ochracea clinical isolate and amplified using primers from the cfxA gene of Bacteroides vulgatus. The MICs of third-generation cephalosporins were much higher than those of the transconjugant Escherichia coli strain. The deduced protein sequence, by comparison with CfxA2 of Prevotella intermedia, had a Y239D substitution and possessed the characteristics of a class A, group 2e beta-lactamase. ...[more]

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