Heterogeneous virulence of pandemic 2009 influenza H1N1 virus in mice.

ABSTRACT:

Background

Understanding the pathogenesis of influenza infection is a key factor leading to the prevention and control of future outbreaks. Pandemic 2009 Influenza H1N1 infection, although frequently mild, led to a severe and fatal form of disease in certain cases that make its virulence nature debatable. Much effort has been made toward explaining the determinants of disease severity; however, no absolute reason has been established.

Results

This study presents the heterogeneous virulence of clinically similar strains of pandemic 2009 influenza virus in human alveolar adenocarcinoma cells and mice. The viruses were obtained from patients who were admitted in a local hospital in China with a similar course of infection and recovered. The A/Nanchang/8002/2009 and A/Nanchang/8

SUBMITTER: Farooqui A 

PROVIDER: S-EPMC3444956 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature