Inhibition of bacterial virulence: drug-like molecules targeting the Salmonella enterica PhoP response regulator.

ABSTRACT: Two-component signal transduction (TCST) is the predominant signaling scheme used in bacteria to sense and respond to environmental changes in order to survive and thrive. A typical TCST system consists of a sensor histidine kinase to detect external signals and an effector response regulator to respond to external changes. In the signaling scheme, the histidine kinase phosphorylates and activates the response regulator, which functions as a transcription factor to modulate gene expression. One promising strategy toward antibacterial development is to target TCST regulatory systems, specifically the response regulators to disrupt the expression of genes important for virulence. In Salmonella enterica, the PhoQ/PhoP signal transduction system is used to sense and respond to low magnesium le

SUBMITTER: Tang YT 

PROVIDER: S-EPMC3445336 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature