Prediction models for risk of developing type 2 diabetes: systematic literature search and independent external validation study.

ABSTRACT:

Objective

To identify existing prediction models for the risk of development of type 2 diabetes and to externally validate them in a large independent cohort.

Data sources

Systematic search of English, German, and Dutch literature in PubMed until February 2011 to identify prediction models for diabetes.

Design

Performance of the models was assessed in terms of discrimination (C statistic) and calibration (calibration plots and Hosmer-Lemeshow test).The validation study was a prospective cohort study, with a case cohort study in a random subcohort.

Setting

Models were applied to the Dutch cohort of the European Prospective Investigation into Cancer and Nutrition cohort study (EPIC-NL).

Participants

38,379 people aged 20-70 with no diabetes at baseline, 25

SUBMITTER: Abbasi A 

PROVIDER: S-EPMC3445426 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature