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Differential gene and microRNA expression between etoposide resistant and etoposide sensitive MCF7 breast cancer cell lines.

ABSTRACT: In order to develop targeted strategies for combating drug resistance it is essential to understand it's basic molecular mechanisms. In an exploratory study we have found several possible indicators of etoposide resistance operating in MCF7VP cells, including up-regulation of ABC transporter genes, modulation of miRNA, and alteration in copy numbers of genes.

SUBMITTER: Moitra K 

PROVIDER: S-EPMC3445463 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature

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Differential gene and microRNA expression between etoposide resistant and etoposide sensitive MCF7 breast cancer cell lines.

Moitra Karobi K   Im Kate K   Limpert Katy K   Borsa Alexander A   Sawitzke Julie J   Robey Rob R   Yuhki Naoya N   Savan Ram R   Huang Da Wei da W   Lempicki Richard A RA   Bates Susan S   Dean Michael M  

PloS one 20120918 9

In order to develop targeted strategies for combating drug resistance it is essential to understand it's basic molecular mechanisms. In an exploratory study we have found several possible indicators of etoposide resistance operating in MCF7VP cells, including up-regulation of ABC transporter genes, modulation of miRNA, and alteration in copy numbers of genes. ...[more]

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