Transcriptional regulation of flotillins by the extracellularly regulated kinases and retinoid X receptor complexes.

ABSTRACT: Flotillin-1 and flotillin-2 are important regulators of signal transduction pathways such as growth factor signaling. Flotillin expression is increased under pathological conditions such as neurodegenerative disorders and cancer. Despite their importance for signal transduction, very little is known about the transcriptional regulation of flotillins. Here, we analyzed the expression of flotillins at transcriptional level and identified flotillins as downstream targets of the mitogen activated kinases ERK1/2. The promoter activity of flotillins was increased upon growth factor stimulation in a MAPK dependent manner. Overexpression of serum response factor or early growth response gene 1 resulted in increased flotillin mRNA and protein expression. Furthermore, both promoter activity and expr

SUBMITTER: Banning A 

PROVIDER: S-EPMC3445523 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature