Replication study in Chinese population and meta-analysis supports association of the 11q23 locus with colorectal cancer.

ABSTRACT:

Background

A common single nucleotide polymorphism (SNP), rs3802842, located at 11q23, was identified by genome-wide association studies (GWAS) to be significantly associated with the risk of colorectal cancer (CRC); however, the results of following replication studies were not always concordant. Thus, a case-control study and a meta-analysis were performed to clearly discern the effect of this variant in CRC.

Method and findings

We determined the genotypes of rs3802842 in 641 unrelated Chinese patients with CRC and 1037 cancer-free controls. Additionally, a meta-analysis comprising current and previously published studies was conducted. In our case-control study, significant associations between the polymorphism and CRC risk were observed in all genetic models, with an add

SUBMITTER: Zou L 

PROVIDER: S-EPMC3445543 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature