Associations of cortical thickness and cognition in patients with schizophrenia and healthy controls.

ABSTRACT: Previous studies have found varying relationships between cognitive functioning and brain volumes in patients with schizophrenia. However, cortical thickness may more closely reflect cytoarchitectural characteristics than gray matter density or volume estimates. Here, we aimed to compare associations between regional variation in cortical thickness and executive functions, memory, as well as verbal and spatial processing in patients with schizophrenia and healthy controls (HCs). We obtained magnetic resonance imaging and neuropsychological data for 131 patients and 138 matched controls. Automated cortical pattern matching methods allowed testing for associations with cortical thickness estimated as the shortest distance between the gray/white matter border and the pial surface at thousands

SUBMITTER: Ehrlich S 

PROVIDER: S-EPMC3446215 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature