Pharmacological augmentation strategies for schizophrenia patients with insufficient response to clozapine: a quantitative literature review.

ABSTRACT:

Background

When schizophrenia patients have insufficient response to clozapine, pharmacological augmentation is often applied. This meta-analysis summarizes available evidence on efficacy of pharmacological augmentation of clozapine treatment in schizophrenia spectrum disorder.

Methods

Only double-blind randomized controlled studies were included. Primary outcome measure was total symptom severity, and secondary outcome measures were subscores for positive and negative symptoms. Effect sizes were calculated from individual studies and combined to standardized mean differences (Hedges's g).

Results

Twenty-nine studies reporting on 15 different augmentations were included. Significant better efficacy than placebo on total symptom severity was observed for lamotrigine, c

SUBMITTER: Sommer IE 

PROVIDER: S-EPMC3446238 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature