Genetic basis of transcriptome differences between the founder strains of the rat HXB/BXH recombinant inbred panel.

ABSTRACT:

Background

With the advent of next generation sequencing it has become possible to detect genomic variation on a large scale. However, predicting which genomic variants are damaging to gene function remains a challenge, as knowledge of the effects of genomic variation on gene expression is still limited. Recombinant inbred panels are powerful tools to study the cis and trans effects of genetic variation on molecular phenotypes such as gene expression.

Results

We generated a comprehensive inventory of genomic differences between the two founder strains of the rat HXB/BXH recombinant inbred panel: SHR/OlaIpcv and BN-Lx/Cub. We identified 3.2 million single nucleotide variants, 425,924 small insertions and deletions, 907 copy number changes and 1,094 large structural genetic va

SUBMITTER: Simonis M 

PROVIDER: S-EPMC3446305 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature