Regulation of alternative splicing by the circadian clock and food related cues.

ABSTRACT:

Background

The circadian clock orchestrates daily rhythms in metabolism, physiology and behaviour that allow organisms to anticipate regular changes in their environment, increasing their adaptation. Such circadian phenotypes are underpinned by daily rhythms in gene expression. Little is known, however, about the contribution of post-transcriptional processes, particularly alternative splicing.

Results

Using Affymetrix mouse exon-arrays, we identified exons with circadian alternative splicing in the liver. Validated circadian exons were regulated in a tissue-dependent manner and were present in genes with circadian transcript abundance. Furthermore, an analysis of circadian mutant Vipr2-/- mice revealed the existence of distinct physiological pathways controlling circadian a

SUBMITTER: McGlincy NJ 

PROVIDER: S-EPMC3446320 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature