Gene expression in extratumoral microenvironment predicts clinical outcome in breast cancer patients.

ABSTRACT:

Introduction

A gene expression signature indicative of activated wound responses is common to more than 90% of non-neoplastic tissues adjacent to breast cancer, but these tissues also exhibit substantial heterogeneity. We hypothesized that gene expression subtypes of breast cancer microenvironment can be defined and that these microenvironment subtypes have clinical relevance.

Methods

Gene expression was evaluated in 72 patient-derived breast tissue samples adjacent to invasive breast cancer or ductal carcinoma in situ. Unsupervised clustering identified two distinct gene expression subgroups that differed in expression of genes involved in activation of fibrosis, cellular movement, cell adhesion and cell-cell contact. We evaluated the prognostic relevance of extratumoral su

SUBMITTER: Roman-Perez E 

PROVIDER: S-EPMC3446385 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature