Bias in effect size of systemic lupus erythematosus susceptibility loci across Europe: a case-control study.

ABSTRACT:

Introduction

We aimed to investigate whether the effect size of the systemic lupus erythematosus (SLE) risk alleles varies across European subpopulations.

Methods

European SLE patients (n = 1,742) and ethnically matched healthy controls (n = 2,101) were recruited at 17 centres from 10 different countries. Only individuals with self-reported ancestry from the country of origin were included. In addition, participants were genotyped for top ancestry informative markers and for 25 SLE associated SNPs. The results were used to compare effect sizes between the Central Eureopan and Southern European subgroups.

Results

Twenty of the 25 SNPs showed independent association with SLE, These SNPs showed a significant bias to larger effect sizes in the Southern subgroup, with 15/2

SUBMITTER: Alonso-Perez E 

PROVIDER: S-EPMC3446468 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature