A Prevalence of Imprinted Genes within the Total Transcriptomes of Human Tissues and Cells.

ABSTRACT: Genomic imprinting is an epigenetic phenomenon that causes a differential expression of paternally and maternally inherited alleles of a subset of genes (the so-called imprinted genes). Imprinted genes are distributed throughout the genome and it is predicted that about 1% of the human genes may be imprinted. It is recognized that the allelic expression of imprinted genes varies between tissues and developmental stages. The current study represents the first attempt to estimate a prevalence of imprinted genes within the total human transcriptome. In silico analysis of the normalized expression profiles of a comprehensive panel of 173 established and candidate human imprinted genes was performed, in 492 publicly available SAGE libraries. The latter represent human cell and tissue samples in

SUBMITTER: Anisimov SV 

PROVIDER: S-EPMC3446743 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature