Ten-m3 is required for the development of topography in the ipsilateral retinocollicular pathway.

ABSTRACT:

Background

The alignment of ipsilaterally and contralaterally projecting retinal axons that view the same part of visual space is fundamental to binocular vision. While much progress has been made regarding the mechanisms which regulate contralateral topography, very little is known of the mechanisms which regulate the mapping of ipsilateral axons such that they align with their contralateral counterparts.

Results

Using the advantageous model provided by the mouse retinocollicular pathway, we have performed anterograde tracing experiments which demonstrate that ipsilateral retinal axons begin to form terminal zones (TZs) in the superior colliculus (SC), within the first few postnatal days. These appear mature by postnatal day 11. Importantly, TZs formed by ipsilaterally-proj

SUBMITTER: Dharmaratne N 

PROVIDER: S-EPMC3446960 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature