Association study of genes associated to asthma in a specific environment, in an asthma familial collection located in a rural area influenced by different industries.

ABSTRACT: Eight candidate genes selected in this study were previously associated with gene-environment interactions in asthma in an urban area. These genes were analyzed in a familial collection from a founder and remote population (Saguenay-Lac-Saint-Jean; SLSJ) located in an area with low air levels of ozone but with localized areas of relatively high air pollutant levels, such as sulphur dioxide, when compared to many urban areas. Polymorphisms (SNPs) were extracted from the genome-wide association study (GWAS) performed on the SLSJ familial collection. A transmission disequilibrium test (TDT) was performed using the entire family sample (1,428 individuals in 254 nuclear families). Stratification according to the proximity of aluminium, pulp and paper industries was also analyzed. Two genes were

SUBMITTER: Morin A 

PROVIDER: S-EPMC3447577 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature