Evaluation of developmental changes in bovine in vitro produced embryos following exposure to bovine Herpesvirus type 5.

ABSTRACT:

Background

Bovine Herpesvirus type-5 (BoHV-5) is a neurovirulent α-Herpesvirus which is potentially pathogenic for cows and suspected to be associated with reproductive disorders. Interestingly, natural transmission of BoHV-5 by contaminated semen was recently described in Australia. Additionally, BoHV-5 was also isolated from the semen of a healthy bull in the same country and incriminated in a natural outbreak of reproductive disease after artificial insemination. In contrast with BoHV-1, experimental exposure of in vitro produced bovine embryos to BoHV-5 does not affect embryo viability and seems to inhibit some pathways of apoptosis. However, the mechanisms responsible for these phenomena are poorly understood. In this study, we examined mitochondrial activity, antioxidant prot

SUBMITTER: Brenner MP 

PROVIDER: S-EPMC3447700 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature