Glomerular hyperfiltration and renal disease progression in type 2 diabetes.

ABSTRACT:

Objective

To describe the prevalence and determinants of hyperfiltration (glomerular filtration rate [GFR] ≥120 mL/min/1.73 m(2)), GFR decline, and nephropathy onset or progression in type 2 diabetic patients with normo- or microalbuminuria.

Research design and methods

We longitudinally studied 600 hypertensive type 2 diabetic patients with albuminuria <200 μg/min and who were retrieved from two randomized trials testing the renal effect of trandolapril and delapril. Target blood pressure (BP) was <120/80 mmHg, and HbA(1c) was <7%. GFR, albuminuria, and glucose disposal rate (GDR) were centrally measured by iohexol plasma clearance, nephelometry in three consecutive overnight urine collections, and hyperinsulinemic euglycemic clamp, respectively.

Results

Over a median

SUBMITTER: Ruggenenti P 

PROVIDER: S-EPMC3447826 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature