Ex vivo and in silico feasibility study of monitoring electric field distribution in tissue during electroporation based treatments.

ABSTRACT: Magnetic resonance electrical impedance tomography (MREIT) was recently proposed for determining electric field distribution during electroporation in which cell membrane permeability is temporary increased by application of an external high electric field. The method was already successfully applied for reconstruction of electric field distribution in agar phantoms. Before the next step towards in vivo experiments is taken, monitoring of electric field distribution during electroporation of ex vivo tissue ex vivo and feasibility for its use in electroporation based treatments needed to be evaluated. Sequences of high voltage pulses were applied to chicken liver tissue in order to expose it to electric field which was measured by means of MREIT. MREIT was also evaluated for its use in elec

SUBMITTER: Kranjc M 

PROVIDER: S-EPMC3447863 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature