Metastable differentially methylated regions within Arabidopsis inbred populations are associated with modified expression of non-coding transcripts.

ABSTRACT: Individual plants within a population may vary at both genetic and epigenetic levels. The rate of genetic divergence and its underlying mechanisms is well understood. Less is known about the factors contributing to epigenetic divergence among isogenic populations except that, despite the presence of mechanisms that faithfully maintain epigenetic marks, epigenetic differences are more frequent than genetic variation. Epigenetically divergent stretches of isogenic DNA sequence are called epialleles. Currently, it is not clear why certain regions exhibit variable epigenetic status. We identified and characterised two long RNA transcripts with altered expression and DNA methylation in an ago5 mutant. However, further investigation revealed that these changes were not dependent upon AGO5. Rathe

SUBMITTER: Havecker ER 

PROVIDER: S-EPMC3447930 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature