Epidemiological profiles between equol producers and nonproducers: a genomewide association study of the equol-producing phenotype.

ABSTRACT: Equol is a daidzein (a phytoestrogen isoflavone) metabolite of gut bacteria, and the ability to produce equol varies between individuals and reduces the risks of several diseases. We tested the effects of equol production on health in Koreans and identified the genetic factors that determine the equol-producing phenotype. In 1391 subjects, the equol-producing phenotype was determined, based on measurements of serum equol concentrations. The anthropometric and blood biochemical measurements between equol producers and nonproducers were analyzed by LC-MS/MS. Genetic factors were identified in a genomewide association study (GWAS), and the interaction between genetic factors and the equol-producing phenotype was examined. We observed that 70.1 % of the study population produced equol. Blood p

SUBMITTER: Hong KW 

PROVIDER: S-EPMC3448036 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature