Phylogenetic structure and evolution of regulatory genes and integrases of P2-like phages.

ABSTRACT: The phylogenetic relationships and structural similarities of the proteins encoded within the regulatory region (containing the integrase gene and the lytic-lysogenic transcriptional switch genes) of P2-like phages were analyzed, and compared with the phylogenetic relationship of P2-like phages inferred from four structural genes. P2-like phages are thought to be one of the most genetically homogenous phage groups but the regulatory region nevertheless varies extensively between different phage genomes.   The analyses showed that there are many types of regulatory regions, but two types can be clearly distinguished; regions similar either to the phage P2 or to the phage 186 regulatory regions. These regions were also found to be most frequent among the sequenced P2-like phage or prophage

SUBMITTER: Nilsson H 

PROVIDER: S-EPMC3448106 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature