Psychotic symptoms and gray matter deficits in clinical pediatric populations.

ABSTRACT:

Background

Neuroanatomic studies have not yet addressed how subtle phenotypic distinctions in psychosis alter the underlying brain changes, and whether there is evidence for psychosis as a dimensional construct. We explored the relationship of cortical GM thickness to psychotic phenotypes in children.

Methods

Cross-sectional comparison of anatomic brain imaging between patients referred as childhood-onset schizophrenia (COS) but ruled out after a drug free inpatient observation. Groups included: patients with no evidence of psychosis (n=22) after drug free observation, patients with psychosis not otherwise specified (PNOS; total n=29) further divided into those without other axis I diagnoses (n=13) and those with other axis I comorbidities (n=16), age/sex matched COS patient

SUBMITTER: Gogtay N 

PROVIDER: S-EPMC3448116 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature