Crystal structure of human enterovirus 71.

ABSTRACT: Enterovirus 71 is a picornavirus associated with fatal neurological illness in infants and young children. Here, we report the crystal structure of enterovirus 71 and show that, unlike in other enteroviruses, the "pocket factor," a small molecule that stabilizes the virus, is partly exposed on the floor of the "canyon." Thus, the structure of antiviral compounds may require a hydrophilic head group designed to interact with residues at the entrance of the pocket.

SUBMITTER: Plevka P 

PROVIDER: S-EPMC3448362 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature