Defining the molecular nexus of cancer, type 2 diabetes and cardiovascular disease.

ABSTRACT: The metabolic syndrome is characterized by a state of metabolic dysfunction resulting in the development of several chronic diseases that are potentially deadly. These metabolic deregulations are complex and intertwined and it has been observed that many of the mechanisms and pathways responsible for diseases characterizing the metabolic syndrome such as type 2 diabetes and cardiovascular disease are linked with cancer development as well. Identification of molecular pathways common to these diverse diseases may prove to be a critical factor in disease prevention and development of potential targets for therapeutic treatments. This review focuses on several molecular pathways, including AMPK, PPARs and FASN that interconnect cancer development, type 2 diabetes and cardiovascular disease. A

SUBMITTER: Cabarcas SM 

PROVIDER: S-EPMC3448443 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature