Exploiting protein-protein interaction networks for genome-wide disease-gene prioritization.

ABSTRACT: Complex genetic disorders often involve products of multiple genes acting cooperatively. Hence, the pathophenotype is the outcome of the perturbations in the underlying pathways, where gene products cooperate through various mechanisms such as protein-protein interactions. Pinpointing the decisive elements of such disease pathways is still challenging. Over the last years, computational approaches exploiting interaction network topology have been successfully applied to prioritize individual genes involved in diseases. Although linkage intervals provide a list of disease-gene candidates, recent genome-wide studies demonstrate that genes not associated with any known linkage interval may also contribute to the disease phenotype. Network based prioritization methods help highlighting such as

SUBMITTER: Guney E 

PROVIDER: S-EPMC3448640 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature