Predicting metabolic pathways of small molecules and enzymes based on interaction information of chemicals and proteins.

ABSTRACT: Metabolic pathway analysis, one of the most important fields in biochemistry, is pivotal to understanding the maintenance and modulation of the functions of an organism. Good comprehension of metabolic pathways is critical to understanding the mechanisms of some fundamental biological processes. Given a small molecule or an enzyme, how may one identify the metabolic pathways in which it may participate? Answering such a question is a first important step in understanding a metabolic pathway system. By utilizing the information provided by chemical-chemical interactions, chemical-protein interactions, and protein-protein interactions, a novel method was proposed by which to allocate small molecules and enzymes to 11 major classes of metabolic pathways. A benchmark dataset consisting of 3,34

SUBMITTER: Gao YF 

PROVIDER: S-EPMC3448724 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature