Brain MRI markers and dropout in a longitudinal study of cognitive aging: the Three-City Dijon Study.

ABSTRACT:

Objective

Longitudinal studies of dementia rely on the assumption that individuals who drop out are comparable to those who remain in the study, adjusting for measured covariates. Existing methods to handle dropouts account for differences based on past health and cognitive measures. We assess whether such adjustments fully account for differences in future dementia risk.

Methods

Among Three-City Study participants in Dijon, France, with 1 (n = 1,633) or 2 (n = 1,168) brain MRI scans, we tested whether white matter lesion volume (WMLV), hippocampal volume, or brain CSF volume predicted dropout ("unable to contact" or "refused interview") in repeated-measures logistic regression with up to 4 follow-ups (average 3.5 waves). Using linear regression, we also estimated difference

SUBMITTER: Glymour MM 

PROVIDER: S-EPMC3448743 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature