Age at onset of epilepsy, pharmacoresistance, and cognitive outcomes: a prospective cohort study.

ABSTRACT:

Objectives

Increasing evidence suggests that uncontrolled seizures have deleterious effects on cognition and behavior, particularly in the developing brain.

Methods

In a community-based cohort, 198 children, aged <8 years with new-onset epilepsy were followed prospectively and reassessed with the Wechsler Intelligence Scales for Children, Third Edition (WISC-III) 8-9 years later. Linear regression analyses with interactions between age at onset (age) and pharmacoresistance (PR) were used to test whether earlier onset conveyed greater vulnerability to the effects of uncontrolled seizures. Full-scale IQ (FSIQ) and the 4 subdomain scores were examined. Adjustment for adaptive behavior scores in a subset was performed. A dichotomous indicator for IQ <80 or ≥80 was used to permit

SUBMITTER: Berg AT 

PROVIDER: S-EPMC3448745 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature