Vitamin D, cognition, and dementia: a systematic review and meta-analysis.

ABSTRACT:

Objective

To examine the association between cognitive function and dementia with vitamin D concentration in adults.

Methods

Five databases were searched for English-language studies up to August 2010, and included all study designs with a comparative group. Cognitive function or impairment was defined by tests of global or domain-specific cognitive performance and dementia was diagnosed according to recognized criteria. A vitamin D measurement was required. Two authors independently extracted data and assessed study quality using predefined criteria. The Q statistic and I² methods were used to test for heterogeneity. We conducted meta-analyses using random effects models for the weighted mean difference (WMD) and Hedge's g.

Results

Thirty-seven studies were included;

SUBMITTER: Balion C 

PROVIDER: S-EPMC3448747 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature