Diversity of antigen-specific responses induced in vivo with CTLA-4 blockade in prostate cancer patients.

ABSTRACT: CTLA-4 is a surface receptor on activated T cells that delivers an inhibitory signal, serving as an immune checkpoint. Treatment with anti-CTLA-4 Abs can induce clinical responses to different malignancies, but the nature of the induced Ag-specific recognition is largely unknown. Using microarrays spotted with >8000 human proteins, we assessed the diversity of Ab responses modulated by treatment with CTLA-4 blockade and GM-CSF. We find that advanced prostate cancer patients who clinically respond to treatment also develop enhanced Ab responses to a higher number of Ags than nonresponders. These induced Ab responses targeted Ags to which preexisting Abs are more likely to be present in the clinical responders compared with nonresponders. The majority of Ab responses are patient-specific, bu

SUBMITTER: Kwek SS 

PROVIDER: S-EPMC3448828 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature