Reversal of atopic dermatitis with narrow-band UVB phototherapy and biomarkers for therapeutic response.

ABSTRACT:

Background

Atopic dermatitis (AD) is a common inflammatory skin disease exhibiting a predominantly T(H)2/"T22" immune activation and a defective epidermal barrier. Narrow-band UVB (NB-UVB) is considered an efficient treatment for moderate-to-severe AD. In patients with psoriasis, NB-UVB has been found to suppress T(H)1/T(H)17 polarization, with subsequent reversal of epidermal hyperplasia. The immunomodulatory effects of this treatment are largely unknown in patients with AD.

Objective

We sought to evaluate the effects of NB-UVB on immune and barrier abnormalities in patients with AD, aiming to establish reversibility of disease and biomarkers of therapeutic response.

Methods

Twelve patients with moderate-to-severe chronic AD received NB-UVB phototherapy 3 times weekl

SUBMITTER: Tintle S 

PROVIDER: S-EPMC3448950 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature