Decreased insulin sensitivity and increased oxidative damage in wasting adipose tissue depots of wild-type mice.

ABSTRACT: Unintentional weight loss (wasting) in the elderly is a major health concern as it leads to increased mortality. Several studies have focused on muscle loss, but little is known about the mechanisms giving rise to loss of fat mass at old ages. To investigate potential mechanisms, white adipose tissue (WAT) characteristics and proteomic profiles were compared between adult (10-12-month-old) and aged (22-24-month-old) wild-type mice. Four individual WAT depots were analyzed to account for possible depot-specific differences. Proteomic profiles of WAT depots, along with body weights and compositions, plasma levels of insulin, leptin and adiponectin, insulin tolerance, adipocyte sizes, and products of oxidative damage in each WAT depot were determined. We found that lean mass remained constant

SUBMITTER: Sackmann-Sala L 

PROVIDER: S-EPMC3448990 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature