Comparative analysis of Wolbachia surface protein in D. melanoagster, A. tabida and B. malayi.

ABSTRACT: Wolbachia surface protein (WSP) is an eight beta-barrel transmembrane structure which participates in host immune response, cell proliferation, pathogenicity and controlled cell death program. The protein has four extracellular loops containing hyper variable regions separated by conserved regions. The WSP structure is homologous to Neisseria surface protein (Nsp A) which has about 34% similarity including antigenic variation and hydrophilicity. Recombination has a large impact on diversity of this protein including positive selection which is major constraint on protein evolution. The molecular mechanism through which Wolbachia induces various reproductive anomalies is unclear; a key feature observed for such anomalies might be because of Wolbachia undergoing extensive recombination. In W

SUBMITTER: Uday J 

PROVIDER: S-EPMC3449380 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature