Meta-analysis of the relationship between common type 2 diabetes risk gene variants with gestational diabetes mellitus.

ABSTRACT:

Background

A number of case-control studies were conducted to investigate the association of common type 2 diabetes (T2D) risk gene polymorphisms with gestational diabetes mellitus (GDM). However, these studies have yielded contradictory results. We therefore performed a meta-analysis to derive a more precise estimation of the association between these polymorphisms and GDM, hence achieve a better understanding to the relationship between T2D and GDM.

Methods

PubMed, EMBASE, ISI web of science and the Chinese National Knowledge Infrastructure databases were systematically searched to identify relevant studies. Data were abstracted independently by two reviewers. A meta-analysis was performed to examine the association between 9 polymorphisms from 8 genes and susceptibility t

SUBMITTER: Mao H 

PROVIDER: S-EPMC3454322 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature