Overexpression of miR-30b in the developing mouse mammary gland causes a lactation defect and delays involution.

ABSTRACT:

Background

MicroRNA (miRNA) are negative regulators of gene expression, capable of exerting pronounced influences upon the translation and stability of mRNA. They are potential regulators of normal mammary gland development and of the maintenance of mammary epithelial progenitor cells. This study was undertaken to determine the role of miR-30b on the establishment of a functional mouse mammary gland. miR-30b is a member of the miR-30 family, composed of 6 miRNA that are highly conserved in vertebrates. It has been suggested to play a role in the differentiation of several cell types.

Methodology/principal findings

The expression of miR-30b was found to be regulated during mammary gland development. Transgenic mice overexpressing miR-30b in mammary epithelial cells were used

SUBMITTER: Le Guillou S 

PROVIDER: S-EPMC3454336 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature