Comparative genomics of CytR, an unusual member of the LacI family of transcription factors.

ABSTRACT: CytR is a transcription regulator from the LacI family, present in some gamma-proteobacteria including Escherichia coli and known not only for its cellular role, control of transport and utilization of nucleosides, but for a number of unusual structural properties. The present study addressed three related problems: structure of CytR-binding sites and motifs, their evolutionary conservation, and identification of new members of the CytR regulon. While the majority of CytR-binding sites are imperfect inverted repeats situated between binding sites for another transcription factor, CRP, other architectures were observed, in particular, direct repeats. While the similarity between sites for different genes in one genome is rather low, and hence the consensus motif is weak, there is high conse

SUBMITTER: Sernova NV 

PROVIDER: S-EPMC3454398 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature