Alteration of TEAD1 expression levels confers apoptotic resistance through the transcriptional up-regulation of Livin.

ABSTRACT:

Background

TEA domain (TEAD) proteins are highly conserved transcription factors involved in embryonic development and differentiation of various tissues. More recently, emerging evidences for a contribution of these proteins towards apoptosis and cell proliferation regulation have also been proposed. These effects appear to be mediated by the interaction between TEAD and its co-activator Yes-Associated Protein (YAP), the downstream effector of the Hippo tumour suppressor pathway.

Methodology/principal findings

We further investigated the mechanisms underlying TEAD-mediated apoptosis regulation and showed that overexpression or RNAi-mediated silencing of the TEAD1 protein is sufficient to protect mammalian cell lines from induced apoptosis, suggesting a proapoptotic function

SUBMITTER: Landin Malt A 

PROVIDER: S-EPMC3454436 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature