Y chromosome gene expression in the blood of male patients with ischemic stroke compared with male controls.

ABSTRACT:

Background

Sex is suggested to be an important determinant of ischemic stroke risk factors, etiology, and outcome. However, the basis for this remains unclear. The Y chromosome is unique in males. Genes expressed in males on the Y chromosome that are associated with stroke may be important genetic contributors to the unique features of males with ischemic stroke, which would be helpful for explaining sex differences observed between men and women.

Objective

We compared Y chromosome gene expression in males with ischemic stroke and male controls.

Methods

Blood samples were obtained from 40 male patients ≤3, 5, and 24 hours after ischemic stroke and from 41 male controls (July 2003-April 2007). RNA was isolated from blood and was processed using Affymetrix Human U133 Pl

SUBMITTER: Tian Y 

PROVIDER: S-EPMC3454519 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature