The chromosomal passenger complex is required for meiotic acentrosomal spindle assembly and chromosome biorientation.

ABSTRACT: During meiosis in the females of many species, spindle assembly occurs in the absence of the microtubule-organizing centers called centrosomes. In the absence of centrosomes, the nature of the chromosome-based signal that recruits microtubules to promote spindle assembly as well as how spindle bipolarity is established and the chromosomes orient correctly toward the poles is not known. To address these questions, we focused on the chromosomal passenger complex (CPC). We have found that the CPC localizes in a ring around the meiotic chromosomes that is aligned with the axis of the spindle at all stages. Using new methods that dramatically increase the effectiveness of RNA interference in the germline, we show that the CPC interacts with Drosophila oocyte chromosomes and is required for the

SUBMITTER: Radford SJ 

PROVIDER: S-EPMC3454873 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature