The relation of codon bias to tissue-specific gene expression in Arabidopsis thaliana.

ABSTRACT: The codon composition of coding sequences plays an important role in the regulation of gene expression. Herein, we report systematic differences in the usage of synonymous codons among Arabidopsis thaliana genes that are expressed specifically in distinct tissues. Although we observed that both regionally and transcriptionally associated mutational biases were associated significantly with codon bias, they could not explain the observed differences fully. Similarly, given that transcript abundances did not account for the differences in codon usage, it is unlikely that selection for translational efficiency can account exclusively for the observed codon bias. Thus, we considered the possible evolution of codon bias as an adaptive response to the different abundances of tRNAs in different t

SUBMITTER: Camiolo S 

PROVIDER: S-EPMC3454886 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature