The large conductance calcium-activated K(+) channel interacts with the small GTPase Rab11b.

ABSTRACT: The transduction of sound by the receptor or hair cells of the cochlea leads to the activation of ion channels found in the basal and lateral regions of these cells. Thus, the processing of these transduced signals to the central nervous system is tied to the regulation of baso-lateral ion channels. The large conductance calcium-activated potassium or BK channel was revealed to interact with the small GTPase, Rab11b, which is one of many Rabs found in various endosomal pathways. Immunoelectron microscopy showed the colocalization of these two proteins in receptor cells and auditory neurons. Using Chinese hamster ovary cells as a heterologous expression system, Rab11b increased or decreased BK expression, depending on the overexpression or RNAi knockdown of Rab, respectively. Additional mut

SUBMITTER: Sokolowski S 

PROVIDER: S-EPMC3455130 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature