Analysis of copy number variations in brain DNA from patients with schizophrenia and other psychiatric disorders.

ABSTRACT:

Background

Clinical studies have identified several regions of the genome with copy number variations (CNVs) associated with diverse neurodevelopmental behavioral disorders.

Methods

We analyzed 1 million (M) single nucleotide polymorphism genotype arrays for evidence of previously reported recurrent CNVs and enriched genome-wide CNV burden in DNA from 600 brains, including 441 individuals with various psychiatric diagnoses. We explored gene expression in the dorsolateral prefrontal cortex in selected cases with CNVs and in other subjects with Illumina BeadArrays (568 subjects in total) and additionally in 66-92 subjects with quantitative real-time polymerase chain reaction.

Results

The CNVs in previously reported genomic regions were identified in 4 of 193 patients wi

SUBMITTER: Ye T 

PROVIDER: S-EPMC3456994 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature