ZipA is required for FtsZ-dependent preseptal peptidoglycan synthesis prior to invagination during cell division.

ABSTRACT: Rod-shaped bacteria grow by a repetitive cycle of elongation followed by division, and the mechanisms responsible for these two processes have been studied for decades. However, little is known about what happens during the transition between the two activities. At least one event occurs after elongation ends and before division commences, that being the insertion of new cell wall peptidoglycan into a narrowly circumscribed ribbon around midcell where septation is destined to take place. This insertion does not depend on the presence of the septation-specific protein PBP3 and is therefore known as PBP3-independent peptidoglycan synthesis (PIPS). Here we report that only FtsZ and ZipA are required to generate PIPS in wild-type Escherichia coli. PIPS does not require the participation of oth

SUBMITTER: Potluri LP 

PROVIDER: S-EPMC3457195 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature