The molecular basis of wound healing processes induced by lithospermi radix: a proteomics and biochemical analysis.

ABSTRACT: Lithospermi Radix (LR) is an effective traditional Chinese herb in various types of wound healing; however, its mechanism of action remains unknown. A biochemical and proteomic platform was generated to explore the biological phenomena associated with LR and its active component shikonin. We found that both LR ethanol extracts and shikonin are able to promote cell proliferation by up to 25%. The results of proteomic analysis revealed that twenty-two differentially expressed proteins could be identified when fibroblast cells were treated with LR or shikonin. The functions of those proteins are associated with antioxidant activity, antiapoptosis activity, the regulation of cell mobility, the secretion of collagen, the removal of abnormal proteins, and the promotion of cell proliferation, ind

SUBMITTER: Hsiao CY 

PROVIDER: S-EPMC3457683 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature