Etsrp/Etv2 is directly regulated by Foxc1a/b in the zebrafish angioblast.

ABSTRACT:

Rationale

Endothelial cells are developmentally derived from angioblasts specified in the mesodermal germ cell layer. The transcription factor etsrp/etv2 is at the top of the known genetic hierarchy for angioblast development. The transcriptional events that induce etsrp expression and angioblast specification are not well understood.

Objective

We generated etsrp:gfp transgenic zebrafish and used them to identify regulatory regions and transcription factors critical for etsrp expression and angioblast specification from mesoderm.

Methods and results

To investigate the mechanisms that initiate angioblast cell transcription during embryogenesis, we have performed promoter analysis of the etsrp locus in zebrafish. We describe three enhancer elements sufficient for endoth

SUBMITTER: Veldman MB 

PROVIDER: S-EPMC3457812 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature