Evolution of the PWWP-domain encoding genes in the plant and animal lineages.

ABSTRACT:

Background

Conserved domains are recognized as the building blocks of eukaryotic proteins. Domains showing a tendency to occur in diverse combinations ('promiscuous' domains) are involved in versatile architectures in proteins with different functions. Current models, based on global-level analyses of domain combinations in multiple genomes, have suggested that the propensity of some domains to associate with other domains in high-level architectures increases with organismal complexity. Alternative models using domain-based phylogenetic trees propose that domains have become promiscuous independently in different lineages through convergent evolution and are, thus, random with no functional or structural preferences. Here we test whether complex protein architectures have occurred

SUBMITTER: Alvarez-Venegas R 

PROVIDER: S-EPMC3457860 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature