Dataset Information
Research resource: RNA-Seq reveals unique features of the pancreatic ?-cell transcriptome.
Ontology highlight
ABSTRACT:
SUBMITTER: Ku GM
PROVIDER: S-EPMC3458219 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Publications
Research resource: RNA-Seq reveals unique features of the pancreatic β-cell transcriptome.
Molecular endocrinology (Baltimore, Md.) 20120821 10
The pancreatic β-cell is critical for the maintenance of glycemic control. Knowing the compendium of genes expressed in β-cells will further our understanding of this critical cell type and may allow the identification of future antidiabetes drug targets. Here, we report the use of next-generation sequencing to obtain nearly 1 billion reads from the polyadenylated RNA of islets and purified β-cells from mice. These data reveal novel examples of β-cell-specific splicing events, promoter usage, an ...[more]
