Conditional ablation of brain-derived neurotrophic factor-TrkB signaling impairs striatal neuron development.

ABSTRACT: Neurotrophic factors, such as brain-derived neurotrophic factor (BDNF), are associated with the physiology of the striatum and the loss of its normal functioning under pathological conditions. The role of BDNF and its downstream signaling in regulating the development of the striatum has not been fully investigated, however. Here we report that ablation of Bdnf in both the cortex and substantia nigra depletes BDNF in the striatum, and leads to impaired striatal development, severe motor deficits, and postnatal lethality. Furthermore, striatal-specific ablation of TrkB, the gene encoding the high-affinity receptor for BDNF, is sufficient to elicit an array of striatal developmental abnormalities, including decreased anatomical volume, smaller neuronal nucleus size, loss of dendritic spines,

SUBMITTER: Li Y 

PROVIDER: S-EPMC3458400 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature